Start by selecting your beef. Trim any excess fat and slice the beef against the grain into thin strips, roughly 1/4 inch thick.
In a large mixing bowl, combine the soy sauce, Worcestershire sauce, honey, BBQ sauce, smoked paprika, garlic powder, onion powder, black pepper, cayenne pepper, red pepper flakes (if using), and liquid smoke. Whisk until well combined.
Add the sliced beef to the marinade, ensuring each piece is well coated. Cover and refrigerate for at least 4 hours, preferably overnight.
Preheat your dehydrator or oven to its lowest setting (around 170°F or 77°C). Line baking sheets with parchment paper if using an oven.
Remove the beef from the marinade and arrange the strips in a single layer on your dehydrator trays or baking sheets, ensuring space between each piece.
Dry the beef in the dehydrator for about 4-6 hours or until desired doneness. If using an oven, check periodically to ensure they don't over-dry.
Once dried, remove the jerky and let it cool completely before storing.